Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells

• Autori principali: Xin Miao (Autore), Gilbert Koch (Autore), Sihem Ait-Oudhia (Autore), Robert Straubinger (Autore), William J. Jusko (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2016-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Combinations of gemcitabine and trabectedin exert modest synergistic cytotoxic effects on two pancreatic cancer cell lines. Here, systems pharmacodynamic (PD) models that integrate cellular response data and extend a prototype model framework were developed to characterize dynamic changes in cell cy...