A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain

• Main Authors: Tamio Furuse (Author), Hiroshi Mizuma (Author), Yuuki Hirose (Author), Tomoko Kushida (Author), Ikuko Yamada (Author), Ikuo Miura (Author), Hiroshi Masuya (Author), Hiromasa Funato (Author), Masashi Yanagisawa (Author), Hirotaka Onoe (Author), Shigeharu Wakana (Author)
• Format: Book
• Published: The Company of Biologists, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysfunction of glucose transporter 1 (GLUT1) proteins causes infantile epilepsy, which is designated as a GLUT1 deficiency syndrome (GLUT1DS; OMIM #606777). Patients with GLUT1DS display varied clinical phenotypes, such as infantile seizures, ataxia, severe mental retardation with learning disabilit...