Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics

• Main Authors: Bharathikumar Vellalore Maruthachalam (Author), Adam Zwolak (Author), Xiefan Lin-Schmidt (Author), Edward Keough (Author), Ninkka Tamot (Author), Sathya Venkataramani (Author), Brian Geist (Author), Sanjaya Singh (Author), Rajkumar Ganesan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mucosal immunity is dominated by secretory IgA and IgM, although these are less favorable compared to IgG molecules for therapeutic development. Polymeric IgA and IgM are actively transported across the epithelial barrier via engagement of the polymeric Ig receptor (pIgR), but IgG molecules lack a l...