Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor

• Главные авторы: Xiangling Cui (Автор), Rui Zhou (Автор), Chenchao Huang (Автор), Rongyu Zhang (Автор), Jing Wang (Автор), Yongxin Zhang (Автор), Jiwei Ding (Автор), Xiaoyu Li (Автор), Jinming Zhou (Автор), Shan Cen (Автор)
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• Опубликовано: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Предметы: article
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Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral heterodimeric serine protease NS2B-NS3 plays...