Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor

• Main Authors: Xiangling Cui (Author), Rui Zhou (Author), Chenchao Huang (Author), Rongyu Zhang (Author), Jing Wang (Author), Yongxin Zhang (Author), Jiwei Ding (Author), Xiaoyu Li (Author), Jinming Zhou (Author), Shan Cen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral heterodimeric serine protease NS2B-NS3 plays...