Dopamine D2-Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine Receptors

• Main Authors: Masashi Yasuda (Author), Ryoji Kawahara (Author), Hiroshi Hashimura (Author), Naoki Yamanaka (Author), Maho Iimori (Author), Kikuko Amagase (Author), Shinichi Kato (Author), Koji Takeuchi (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: We have reported that nicotine and the specific α7AChR agonist ameliorate indomethacin-induced intestinal lesions in mice by activating α7 nicotinic acetylcholine receptors (α7nAChR). Dopamine D2-receptor antagonists, such as domperidone and metoclopramide, enhance the release of ACh from...