Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy

• المؤلفون الرئيسيون: Stephen A. Jannetti (مؤلف), Brian M. Zeglis (مؤلف), Michael R. Zalutsky (مؤلف), Thomas Reiner (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic lethality in cells where the homologous recombinat...