Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−

Abstract Deficiencies in N‐methyl‐d‐aspartate (NMDA)/glutamate receptor (NMDAR) signaling have been considered central to the cognitive impairments of schizophrenia; however, an NMDAR antagonist memantine (MEM) improves cognitive impairments of Alzheimer's disease and schizophrenia. These mecha...

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Main Authors: Motohiro Okada (Author), Kouji Fukuyama (Author), Yasuhiro Kawano (Author), Takashi Shiroyama (Author), Yuto Ueda (Author)
Formato: Livro
Publicado em: Wiley, 2019-02-01T00:00:00Z.
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