Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc−

• Main Authors: Motohiro Okada (Author), Kouji Fukuyama (Author), Yasuhiro Kawano (Author), Takashi Shiroyama (Author), Yuto Ueda (Author)
• Formato: Livro
• Publicado em: Wiley, 2019-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Deficiencies in N‐methyl‐d‐aspartate (NMDA)/glutamate receptor (NMDAR) signaling have been considered central to the cognitive impairments of schizophrenia; however, an NMDAR antagonist memantine (MEM) improves cognitive impairments of Alzheimer's disease and schizophrenia. These mecha...