Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier

Our group has developed and experimentally validated a strategy to increase antibody penetration in solid tumors through transient inhibition of antibody-antigen binding. In prior work, we demonstrated that 1HE, an anti-trastuzumab single domain antibody that transiently inhibits trastuzumab binding...

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Bibliographic Details
Main Authors: Brandon M. Bordeau (Author), Lubna Abuqayyas (Author), Toan D. Nguyen (Author), Ping Chen (Author), Joseph P. Balthasar (Author)
Format: Book
Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available