Determination of nucleoside DOT1L inhibitors' residence times by τRAMD simulations
Human epigenetic enzyme disruptor of telomeric silencing 1-like (DOT1L) is a key drug target for treating acute myeloid leukemia. Several nucleoside and non-nucleoside DOT1L inhibitors have been developed to inhibit its histone methyltransferase activity. Non-mechanism-based nucleoside DOT1L inhibit...
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| Main Authors: | , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2023-01-01T00:00:00Z.
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A1234.567 |
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