LC-MS/MS method for the quantitation of decitabine and venetoclax in rat plasma after SPE: Application to pharmacokinetic study

• Main Authors: Abdulaziz I. Alnasser (Author), Mohamed M. Hefnawy (Author), Abdullah M. Al-Hossaini (Author), Yousef A. Bin Jardan (Author), Adel S. El-Azab (Author), Alaa M. Abdel-Aziz (Author), Abdulrahman M. Al-Obaid (Author), Ibrahim A. Al-Suwaidan (Author), Mohamed W. Attwa (Author), Manal A. El-Gendy (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study developed a novel, sensitive and selective LC-MS/MS method for the concurrent determination of DCB and VTX in rat plasma using encorafenib as internal standard (IS). To identify DCB, VTX, and IS, the positive multiple reaction monitoring (MRM) mode was used. Chromatographic separation was...