Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant <i>Pseudomonas aeruginosa</i>: In Vivo and In Vitro Evidence

• Main Authors: Inmaculada Lopez-Montesinos (Author), María Milagro Montero (Author), Sandra Domene-Ochoa (Author), Carla López-Causapé (Author), Daniel Echeverria (Author), Luisa Sorlí (Author), Nuria Campillo (Author), Sonia Luque (Author), Eduardo Padilla (Author), Nuria Prim (Author), Santiago Grau (Author), Antonio Oliver (Author), Juan P. Horcajada (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study correlates in vivo findings in a patient with an extensively drug-resistant (XDR) <i>P. aeruginosa</i> infection who developed resistance to ceftazidime-avibactam (CAZ-AVI) with in vitro results of a 7-day hollow-fiber infection model (HFIM) testing the same bacterial strain....