Box-Behnken Design-Based Optimization and Evaluation of Lipid-Based Nano Drug Delivery System for Brain Targeting of Bromocriptine

• Main Authors: Asha Spandana K M (Author), Mohit Angolkar (Author), Mohamed Rahamathulla (Author), Kamal Y. Thajudeen (Author), Mohammed Muqtader Ahmed (Author), Syeda Ayesha Farhana (Author), Thippeswamy Boreddy Shivanandappa (Author), Sharanya Paramshetti (Author), Riyaz Ali M. Osmani (Author), Jawahar Natarajan (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bromocriptine (BCR) presents poor bioavailability when administered orally because of its low solubility and prolonged first-pass metabolism. This poses a significant challenge in its utilization as an effective treatment for managing Parkinson's disease (PD). The utilization of lipid nanoparti...