A Physiologically‐Based Pharmacokinetic Model for the Prediction of "Half‐Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics

• Main Authors: Hannah M. Jones (Author), John Tolsma (Author), Zhiwei Zhang (Author), Paul Jasper (Author), Haobin Luo (Author), Gregory L. Weber (Author), Katherine Wright (Author), Joel Bard (Author), Robert Bell (Author), Dean Messing (Author), Kerry Kelleher (Author), Nicole Piche‐Nicholas (Author), Robert Webster (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies (mAbs) can be engineered to have "extended half‐life" and "catch and release" properties to improve target coverage. We have developed a mAb physiologically‐based pharmacokinetic model that describes intracellular trafficking, neonatal Fc receptor (FcRn) rec...