A Physiologically‐Based Pharmacokinetic Model for the Prediction of "Half‐Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics
Monoclonal antibodies (mAbs) can be engineered to have "extended half‐life" and "catch and release" properties to improve target coverage. We have developed a mAb physiologically‐based pharmacokinetic model that describes intracellular trafficking, neonatal Fc receptor (FcRn) rec...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Wiley,
2020-09-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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