Increased expression of NLRP3 associated with elevated levels of HMGB1 in children with febrile seizures: a case-control study

• Main Authors: Xing-Guang Ye (Author), Feng-Zhi She (Author), Dong-Ni Yu (Author), Li-Qian Wu (Author), Yan Tang (Author), Ben-Ze Wu (Author), Shi-Wei Dong (Author), Jie-Min Dai (Author), Xing Zhou (Author), Zhi-Gang Liu (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High mobility group box-1 (HMGB1) is an endogenous danger signal that mediates activation of the innate immune response including NLR pyrin domain containing 3 (NLRP3) inflammasome activation and proinflammatory cytokine release. Although HMGB1 and NLRP3 have been implicated in t...