Assessment of E. coli Expression System for Overexpression of Active Recombinant Ocriplasmin

• Main Authors: Roghayyeh Baghban (Author), Safar Farajnia (Author), Younes Ghasemi (Author), Mojtaba Mortazavi (Author), Naser Samadi (Author), Nosratollah Zarghami (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Ocriplasmin (Jetrea TM) is a FDA approved recombinant enzyme utilized in the treatment of vitreomacular adhesion (VMA). This is a recombinant C-terminal fragment of human plasmin produced using yeast Pichia pastoris. Since ocriplasmin does not contain any Oor N-glycosylation or some other p...