Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice

• Main Authors: Tetsuya Ohnou (Author), Masafumi Yokai (Author), Takashi Kurihara (Author), Maiko Hasegawa-Moriyama (Author), Takao Shimizu (Author), Kazuhiko Inoue (Author), Yuki Kambe (Author), Yuichi Kanmura (Author), Atsuro Miyata (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intrathecal (i.t.) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) induces long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet. The present study investigated signaling mechani...