Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

• Main Authors: Prem Singh Kaushal (Author), Qun Wan (Author), Chris G. Dealwis (Author), Jianying Kiser (Author), Hai Xu (Author), James W. Fairman (Author), Andrew Zhang (Author), Sanath R. Wijerathna (Author), Md. Faiz Ahmad (Author)
• Format: Book
• Published: MDPI AG, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and a small subunit called RR2 (β), which houses a tyr...