Design of Smart Nanodiamonds: Introducing pH Sensitivity to Improve Nucleic Acid Carrier Efficiency of Diamoplexes

• Główni autorzy: Saniya Alwani (Autor), Raj Rai (Autor), Isabella Zittlau (Autor), Jonathan Rekve (Autor), Deborah Michel (Autor), Ildiko Badea (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The mechanism of cellular uptake and intracellular fate of nanodiamond/nucleic acid complexes (diamoplexes) are major determinants of its performance as a gene carrier. Our group designed lysine-nanodiamonds (K-NDs) as vectors for nucleic acid delivery. In this work, we modified the surface of K-NDs...