PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity

• Main Authors: Diana M. Shih (Author), Yonghong Meng (Author), Tamer Sallam (Author), Laurent Vergnes (Author), Michelle L. Shu (Author), Karen Reue (Author), Peter Tontonoz (Author), Alan M. Fogelman (Author), Aldons J. Lusis (Author), Srinivasa T. Reddy (Author)
• Format: Book
• Published: MDPI AG, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice are more susceptible to atherosclerosis. Furth...