Berberine and Its Main Metabolite Berberrubine Inhibit Platelet Activation Through Suppressing the Class I PI3Kβ/Rasa3/Rap1 Pathway

• Main Authors: Can Wang (Author), Yangyang Cheng (Author), Yuanhui Zhang (Author), Hongtao Jin (Author), Zengyan Zuo (Author), Aiping Wang (Author), Jianmei Huang (Author), Jiandong Jiang (Author), Weijia Kong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Berberine (BBR), a natural product, was reported to inhibit platelet aggregation; however, the molecular mechanisms remain unclear. This study aims to investigate the effects and mechanisms of BBR in inhibiting platelet activation and thrombus formation.Methods: Flow cytometry, immunoflu...