Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

• Главные авторы: Xiaohua Shen (Автор), Bo Hu (Автор), Guangtao Xu (Автор), Fengjuan Chen (Автор), Ruifen Ma (Автор), Nenghua Zhang (Автор), Jie Liu (Автор), Xiaoqin Ma (Автор), Jia Zhu (Автор), Yuhong Wu (Автор), Ruilin Shen (Автор)
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• Опубликовано: Karger Publishers, 2017-06-01T00:00:00Z.
• Предметы: article
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Background/Aims: Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat m...