Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats

• Main Authors: Xiaohua Shen (Author), Bo Hu (Author), Guangtao Xu (Author), Fengjuan Chen (Author), Ruifen Ma (Author), Nenghua Zhang (Author), Jie Liu (Author), Xiaoqin Ma (Author), Jia Zhu (Author), Yuhong Wu (Author), Ruilin Shen (Author)
• Format: Book
• Published: Karger Publishers, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Diabetes mellitus can exacerbate renal ischemia-reperfusion (I/R) injury (RI/RI). The aim of the present study was to evaluate the protective effect of GSK-3β inhibition (TDZD-8) on I/R-induced renal injury through the Nrf2/HO-1 pathway in a streptozocin (STZ)-induced diabetic rat m...