Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A

• Main Authors: Sindhu Rajan (Author), Lorna M. Dickson (Author), Elizabeth Mathew (Author), Caitlin M.O. Orr (Author), Johanne H. Ellenbroek (Author), Louis H. Philipson (Author), Barton Wicksteed (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous tissues, have diminished dose-response in patients with type 2 diabetes compared with healthy human controls. The aim of thi...