Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A

• 主要な著者: Sindhu Rajan (著者), Lorna M. Dickson (著者), Elizabeth Mathew (著者), Caitlin M.O. Orr (著者), Johanne H. Ellenbroek (著者), Louis H. Philipson (著者), Barton Wicksteed (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2015-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous tissues, have diminished dose-response in patients with type 2 diabetes compared with healthy human controls. The aim of thi...