MutSα and MutSβ as size-dependent cellular determinants for prime editing in human embryonic stem cells

• Autores principales: Ju-Chan Park (Autor), Yun-Jeong Kim (Autor), Jun Hee Han (Autor), Dayeon Kim (Autor), Mihn Jeong Park (Autor), Jumee Kim (Autor), Hyeon-Ki Jang (Autor), Sangsu Bae (Autor), Hyuk-Jin Cha (Autor)
• Formato: Libro
• Publicado: Elsevier, 2023-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Precise genome editing in human pluripotent stem cells (hPSCs) has potential applications in isogenic disease modeling and ex vivo stem cell therapy, necessitating diverse genome editing tools. However, unlike differentiated somatic cells, hPSCs have unique cellular properties that maintain genome i...