Safety, tolerability, and pharmacokinetics of single and multiple topical ophthalmic administration of imatinib mesylate in healthy subjects

• Main Authors: Joo Young Na (Author), Ki Young Huh (Author), Kyung‐Sang Yu (Author), Joon Young Hyon (Author), Hye Cheong Koo (Author), Jong Ho Lee (Author), Ji Chang You (Author), Jae‐Yong Chung (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract For the long‐term efficacy of dry eye disease treatment, relieving underlying inflammation is necessary. Imatinib mesylate is a novel ophthalmic formulation of imatinib mesylate, which is expected to alleviate inflammation by inhibiting the discoidin domain receptor 1 activity. This study a...