Local and Global Protein Interactions Contribute to Residue Entrenchment in Beta-Lactamase TEM-1

• Main Authors: André Birgy (Author), Mélanie Magnan (Author), Claire Amaris Hobson (Author), Matteo Figliuzzi (Author), Karine Panigoni (Author), Cyrielle Codde (Author), Olivier Tenaillon (Author), Hervé Jacquier (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to their rapid evolution and their impact on healthcare, beta-lactamases, protein degrading beta-lactam antibiotics, are used as generic models of protein evolution. Therefore, we investigated the mutation effects in two distant beta-lactamases, TEM-1 and CTX-M-15. Interestingly, we found a site...