Design, Synthesis, and Biological Evaluation of a Novel VEGFR-2 Inhibitor Based on a 1,2,5-Oxadiazole-2-Oxide Scaffold with MAPK Signaling Pathway Inhibition

Over the past few decades, the development of broad-spectrum anticancer agents with anti-angiogenic activity has witnessed considerable progress. In this study, a new series of pyrazolo[3,4-d]pyrimidines based on a phenylfuroxan scaffold were designed, synthesized, and evaluated, in terms of their a...

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Main Authors: Mater H. Mahnashi (Author), Fardous F. El-Senduny (Author), Mohammed Abdulrahman Alshahrani (Author), Mahrous A. Abou-Salim (Author)
Format: Book
Published: MDPI AG, 2022-02-01T00:00:00Z.
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