Feasibility of drug delivery to the eye's posterior segment by topical instillation of PLGA nanoparticles

• Main Authors: Kohei Tahara (Author), Keiichi Karasawa (Author), Risako Onodera (Author), Hirofumi Takeuchi (Author)
• Format: Book
• Published: Elsevier, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the delivery of drugs to the posterior segment of the eye by non-invasive topical instillation using submicron-sized poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs). Surface-modified PLGA NPs were developed to improve the drug delivery efficiency to the retina and were admi...