Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs

Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs

Almost half of orally administered active pharmaceutical ingredients (APIs) have low solubility, which affects their bioavailability. In the last two decades, several alternatives have been proposed to modify the crystalline structure of APIs to improve their solubility; these strategies consist of...

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Main Authors: Luz María Martínez (Author), Jorge Cruz-Angeles (Author), Mónica Vázquez-Dávila (Author), Eduardo Martínez (Author), Paulina Cabada (Author), Columba Navarrete-Bernal (Author), Flor Cortez (Author)
Format: Book
Published: MDPI AG, 2022-09-01T00:00:00Z.
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