In vivo evaluation of two thiazolidin-4-one derivatives in high sucrose diet fed pre-diabetic mice and their modulatory effect on AMPK, Akt and p38 MAP kinase in L6 cells

• Main Authors: Jayesh Mudgal (Author), Priya Shetty (Author), Neetinkumar D Reddy (Author), Akhila H.S (Author), Karthik Gourishetti (Author), Geetha Mathew (Author), Pawan Ganesh Nayak (Author), Nitesh Kumar (Author), Anoop Kishore (Author), Nampurath Gopalan Kutty (Author), Krishnadas Nandakumar (Author), Rekha Raghuveer Shenoy (Author), Chamallamudi Mallikarjuna Rao (Author), Alex Joseph (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We had previously demonstrated the anti-diabetic potential and pancreatic protection of two thiazolidin-4-one derivatives containing nicotinamide moiety (NAT-1 and NAT-2) in STZ-induced diabetic mice. However, due to the limitations of the STZ model, we decided to undertake a detailed evaluation of...