Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension

• Main Authors: Oleksandr Nychyk (Author), Gabriel L. Galea (Author), Matteo Molè (Author), Dawn Savery (Author), Nicholas D. E. Greene (Author), Philip Stanier (Author), Andrew J. Copp (Author)
• Format: Book
• Published: The Company of Biologists, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene mutations but these are heterozygous, not homozygous...