Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension
Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene mutations but these are heterozygous, not homozygous...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2022-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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