Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension

• Hoofdauteurs: Oleksandr Nychyk (Auteur), Gabriel L. Galea (Auteur), Matteo Molè (Auteur), Dawn Savery (Auteur), Nicholas D. E. Greene (Auteur), Philip Stanier (Auteur), Andrew J. Copp (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2022-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Planar cell polarity (PCP) signalling is vital for initiation of mouse neurulation, with diminished convergent extension (CE) cell movements leading to craniorachischisis, a severe neural tube defect (NTD). Some humans with NTDs also have PCP gene mutations but these are heterozygous, not homozygous...