Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys

• Main Authors: Yaofeng Cheng (Author), Xiaomin Liang (Author), Jia Hao (Author), Congrong Niu (Author), Yurong Lai (Author)
• Format: Knjiga
• Izdano: Wiley, 2021-09-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract The impact of organic anion‐transporting polypeptide (OATP) inhibition on systemic and liver exposures of three OATP substrates was investigated in cynomolgus monkeys. A monkey physiologically‐based pharmacokinetic (PBPK) model was constructed to describe the exposure changes followed by OA...