Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats

• Main Authors: Joana Barbosa (Author), Juliana Faria (Author), Fernanda Garcez (Author), Sandra Leal (Author), Luís Pedro Afonso (Author), Ana Vanessa Nascimento (Author), Roxana Moreira (Author), Frederico C. Pereira (Author), Odília Queirós (Author), Félix Carvalho (Author), Ricardo Jorge Dinis-Oliveira (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely prescribed due to the enhanced therapeutic profiles resulting from the synergistic combination between μ-opioid receptor (MOR) activation and monoamine reuptake inhibition. However, the number of adverse reacti...