Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin

• Main Authors: Roberto Chulluncuy (Author), Carlos Espiche (Author), Jose Alberto Nakamoto (Author), Attilio Fabbretti (Author), Pohl Milón (Author)
• Format: Book
• Published: MDPI AG, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them, streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant (MDR) Mycobacterium tuberculosis. Both drugs bind the small ribosomal subunit (30S) and inhibit protein synthesis. Genetic...