Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-<i>d</i>]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme

• Main Authors: Federica Poggialini (Author), Chiara Vagaggini (Author), Annalaura Brai (Author), Claudia Pasqualini (Author), Emmanuele Crespan (Author), Giovanni Maga (Author), Cecilia Perini (Author), Noemi Cabella (Author), Lorenzo Botta (Author), Francesca Musumeci (Author), Maria Frosini (Author), Silvia Schenone (Author), Elena Dreassi (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-<i>d</i>]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual inhibitors. Herein, we present...