Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites

• मुख्य लेखकों: Lingli Mu (लेखक), Rui Zhou (लेखक), Fang Tang (लेखक), Xingling Liu (लेखक), Sanwang Li (लेखक), Feifan Xie (लेखक), Xiang Xie (लेखक), Jie Peng (लेखक), Peng Yu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2016-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5'-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the pharmacokinetics of AZT and its p...