Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites

• Main Authors: Lingli Mu (Author), Rui Zhou (Author), Fang Tang (Author), Xingling Liu (Author), Sanwang Li (Author), Feifan Xie (Author), Xiang Xie (Author), Jie Peng (Author), Peng Yu (Author)
• Format: Book
• Published: Elsevier, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5'-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the pharmacokinetics of AZT and its p...