Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

• Główni autorzy: Agathe Hugele (Autor), Susanne Löffler (Autor), Belén Hernández Molina (Autor), Melina Guillon (Autor), Ahmed B. Montaser (Autor), Seppo Auriola (Autor), Kristiina M. Huttunen (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utilized to release the active parent drug at a particul...