Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain

• Main Authors: Agathe Hugele (Author), Susanne Löffler (Author), Belén Hernández Molina (Author), Melina Guillon (Author), Ahmed B. Montaser (Author), Seppo Auriola (Author), Kristiina M. Huttunen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utilized to release the active parent drug at a particul...