Effect of <i>N</i>-Terminal Peptide Modifications on In Vitro and In Vivo Properties of ¹⁷⁷Lu-Labeled Peptide Analogs Targeting CCK2R

• Main Authors: Anton Amadeus Hörmann (Author), Maximilian Klingler (Author), Christine Rangger (Author), Christian Mair (Author), Lieke Joosten (Author), Gerben M. Franssen (Author), Peter Laverman (Author), Elisabeth von Guggenberg (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The therapeutic potential of minigastrin (MG) analogs for the treatment of cholecystokinin-2 receptor (CCK2R)-expressing cancers is limited by poor in vivo stability or unfavorable accumulation in non-target tissues. Increased stability against metabolic degradation was achieved by modifying the C-t...