Preclinical comparison of [177Lu]Lu-rhPSMA-10.1 and [177Lu]Lu-rhPSMA-10.2 for endoradiotherapy of prostate cancer: biodistribution and dosimetry studies

• Main Authors: Alexander Wurzer (Author), Francesco De Rose (Author), Sebastian Fischer (Author), Markus Schwaiger (Author), Wolfgang Weber (Author), Stephan Nekolla (Author), Hans-Jürgen Wester (Author), Matthias Eiber (Author), Calogero D'Alessandria (Author)
• Format: Book
• Published: SpringerOpen, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Radiohybrid PSMA-targeted ligands (rhPSMA) have been introduced as a novel platform for theranostic applications. Among a variety of rhPSMA-ligands developed for radioligand therapy, two stereoisomers [177Lu]Lu-rhPSMA-10.1 and -10.2 have been synthesized and initially characteriz...