Development of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors

• Main Authors: Richard Graveline (Author), Morad Haida (Author), Carolyne Dumont (Author), Dominic Poulin (Author), Florence Poitout-Belissent (Author), Rana Samadfam (Author), Sven Kronenberg (Author), Franziska Regenass-Lechner (Author), Rodney Prell (Author), Marie-Soleil Piche (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting immune checkpoint receptors expressed in the T cell synapse induces active and long-lasting antitumor immunity in preclinical tumor models and oncology patients. However, traditional nonhuman primate (NHP) studies in healthy animals have thus far demonstrated little to no pharmacological a...