ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI

• Main Authors: Renkan Zhang (Author), Ling Xie (Author), Fangfang Wu (Author), Ji Xu (Author), Leilei Lu (Author), Lin Cao (Author), Lei Li (Author), Weiyang Meng (Author), Hongyu Zhang (Author), Chuxiao Shao (Author), Xiaokun Li (Author), Daqing Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Promoting blood-spinal cord barrier (BSCB) repair at the early stage plays a crucial role in treatment of spinal cord injury (SCI). Excessive activation of autophagy can prevent recovery of BSCB after SCI. Basic fibroblast growth factor (bFGF) has been shown to promote BSCB repair and locomotor func...