An Asymptomatic, Ectopic Mass as a Presentation of Adrenocortical Carcinoma Due to a Novel Germline <i>TP53</i> p.Phe338Leu Tetramerisation Domain Variant

• Main Authors: Justyna Walenciak (Author), Zuzanna Urbanska (Author), Agata Pastorczak (Author), Katarzyna Babol-Pokora (Author), Kamila Wypyszczak (Author), Ewa Bien (Author), Aleksandra Gawlowska-Marciniak (Author), Jozef Kobos (Author), Wieslawa Grajkowska (Author), Joanna Smyczynska (Author), Wojciech Mlynarski (Author), Szymon Janczar (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adrenocortical carcinoma (ACC) is a rare cancer in childhood. ACC is frequently associated with germline <i>TP53</i> variants, with founder effects especially due to the p.Arg337His mutation. ACC leads to the secretion of adrenocortical hormones, resulting in endocrine syndromes, which i...