Murine Models for Trypanosoma brucei gambiense disease progression--from silent to chronic infections and early brain tropism.

• Main Authors: Christiane Giroud (Author), Florence Ottones (Author), Virginie Coustou (Author), Denis Dacheux (Author), Nicolas Biteau (Author), Benjamin Miezan (Author), Nick Van Reet (Author), Mark Carrington (Author), Felix Doua (Author), Théo Baltz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense remains highly prevalent in west and central Africa and is lethal if left untreated. The major problem is that the disease often evolves toward chronic or asymptomatic forms with low and fluctuating parasitaemia producing app...