Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

SUMMARY Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Oxidative stress has been associated with the etiology of both sporadic and monogenic forms of PD. The transcription factor Nrf2, a conserved global regulator of cellular antioxidant responses, has been imp...

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Main Authors: Maria Cecilia Barone (Author), Gerasimos P. Sykiotis (Author), Dirk Bohmann (Author)
Format: Book
Published: The Company of Biologists, 2011-09-01T00:00:00Z.
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3rd Floor Main Library

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