Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

• मुख्य लेखकों: Maria Cecilia Barone (लेखक), Gerasimos P. Sykiotis (लेखक), Dirk Bohmann (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2011-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SUMMARY Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Oxidative stress has been associated with the etiology of both sporadic and monogenic forms of PD. The transcription factor Nrf2, a conserved global regulator of cellular antioxidant responses, has been imp...