Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects

• Main Authors: Feng Lin (Author), Wanhui Lin (Author), Chaofeng Zhu (Author), Jilan Lin (Author), Junge Zhu (Author), Xu-Ying Li (Author), Zhanjun Wang (Author), Chaodong Wang (Author), Huapin Huang (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with neuronal cell inclusions composed of neurofilaments and other abnormal aggregative proteins as pathological hallmarks. Approximately 90% of patients have sporadic cases (sALS), and at least 4 gene...