Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk

• Main Authors: Jiesi Chen (Author), Nadine Haase (Author), Sven-Bastiaan Haange (Author), Robert Sucher (Author), Julia Münzker (Author), Elisabeth Jäger (Author), Kristin Schischke (Author), Florian Seyfried (Author), Martin von Bergen (Author), Mohammed K. Hankir (Author), Ute Krügel (Author), Wiebke K. Fenske (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hypothalamic inflammation and endoplasmic reticulum (ER) stress are extensively linked to leptin resistance and overnutrition-related diseases. Surgical intervention remains the most efficient long-term weight-loss strategy for morbid obesity, but mechanisms underlying sustained feeding s...