Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies

• Κύριοι συγγραφείς: Nathupakorn Dechsupa (Συγγραφέας), Nopawit Khamto (Συγγραφέας), Pornthip Chawapun (Συγγραφέας), Sadanon Siriphong (Συγγραφέας), Phattarawadee Innuan (Συγγραφέας), Authaphinya Suwan (Συγγραφέας), Thitiworada Luangsuep (Συγγραφέας), Nichakorn Photilimthana (Συγγραφέας), Witchayaporn Maita (Συγγραφέας), Rossarin Thanacharttanatchaya (Συγγραφέας), Padchanee Sangthong (Συγγραφέας), Puttinan Meepowpan (Συγγραφέας), Chatchanok Udomtanakunchai (Συγγραφέας), Jiraporn Kantapan (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2023-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Combining phytochemicals with chemotherapeutic drugs has demonstrated the potential to surmount drug resistance. In this paper, we explore the efficacy of pentagalloyl glucose (PGG) in modulating P-gp and reversing multidrug resistance (MDR) in drug-resistant leukemic cells (K562/ADR). The cytotoxic...