Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies

• Main Authors: Nathupakorn Dechsupa (Author), Nopawit Khamto (Author), Pornthip Chawapun (Author), Sadanon Siriphong (Author), Phattarawadee Innuan (Author), Authaphinya Suwan (Author), Thitiworada Luangsuep (Author), Nichakorn Photilimthana (Author), Witchayaporn Maita (Author), Rossarin Thanacharttanatchaya (Author), Padchanee Sangthong (Author), Puttinan Meepowpan (Author), Chatchanok Udomtanakunchai (Author), Jiraporn Kantapan (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combining phytochemicals with chemotherapeutic drugs has demonstrated the potential to surmount drug resistance. In this paper, we explore the efficacy of pentagalloyl glucose (PGG) in modulating P-gp and reversing multidrug resistance (MDR) in drug-resistant leukemic cells (K562/ADR). The cytotoxic...